The HiSeq X Five System enables fast and affordable human whole-genome sequencing on a massive scale. This system offers access to the same patterned flow cell technology that drives the population-scale power of the HiSeq X Ten System. The HiSeq X Five System consists of 5 HiSeq X ultra-high-throughput sequencers, which together can sequence over 9000 genomes per year. This level of throughput allows researchers to complete large human whole-genome sequencing projects rapidly, in their own lab.